Two sample MR report
HLA-DQB1_Endothelial Cell (Endo) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.1715813 | 0.1398082 | 0.2546111 |
| Weighted median | 10 | -0.1803579 | 0.0196695 | 0.0000000 |
| Inverse variance weighted | 10 | -0.1855945 | 0.0127413 | 0.0000000 |
| Simple mode | 10 | -0.1794621 | 0.0298857 | 0.0002013 |
| Weighted mode | 10 | -0.1779964 | 0.0300592 | 0.0002230 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.246208 | 8 | 0.7309661 |
| Inverse variance weighted | 11.814538 | 9 | 0.2239679 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1845141 | 0.071995 | 0.0334968 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001916 | 1.9e-06 | TRUE | 0.2350972 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
